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Headquarters
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| RP.1 Comparative study on HIV/AIDS with Antiretroviral drugs and Anti-retroviral drugs with add on Homeopathy drugs |
| Broad objectives |
- To study clinical progression of disease in both the groups
- To study the immunological project by Absolute CD4 T-lymphocyte count in both the groups
- To study the virological response in both groups by HIV viral load assay
- To study biochemical, hematological and radiological changes in both groups
- To study the emergence of select Opportunistic Infections (OIs) in both groups (i.e. P.corinii & M.tuberculosis)
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| RP.2 Molecular typing of Human Immunodeficiency Virus 1 Strains circulating in India |
| Broad objectives |
- To study genetic diversity within Indian HIV 1 strains based on env, gag & nef genes.
- Cloning and full length genome sequencing of prevalent and recombinant strains.
- Genetic information will help in understanding of molecular epidemiology of HIV-1 in India. It may also help in vaccine development programme
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| RP.3 Molecular Characterization of drug resistance genes of HIV-1 type |
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Broad objectives
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To study genetic diversity within the drug resistant strains of HIV-1 type C using Protease & Integrate genes. Genetic information will help in understanding of molecular epidemiology of drug resistant strain of HIV-1 type C in India.
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| RP.4 Molecular characterization of Dengue virus Type-2 isolates in the Pre-M, M and Env/NS1 gene of region of the virus isolates from Dengue HF outbreaks and field collected mosquitoes |
| Broad objectives |
- Referred and suspected cases of HBV and HCV from different hospitals of Delhi and adjoining areas were confirmed by molecular diagnostic test (PCR/RT-PCR)targeting surface gene, core gene and 5’UTR gene region.
- Genotyping of HBV by sequencing of HBsAg core gene and HCV by 5’UTR gene region to know the prevalence of HBV and HCV subtype in India.
- To know the mode of transmission of these subtypes, and their relatedness with chronicity, drug addiction, carrier state etc.
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| RP.5 Molecular characterization of Dengue virus Type-2 isolates in the Pre-M, M and Env/NS1 gene of region of the virus isolates from Dengue HF outbreaks and field collected mosquitoes. |
| Broad objectives |
- To confirm the dengue out-break from suspected clinical samples with the help of molecular diagnostic test (PCR/RT-PCR).
- To indicate the dengue virus type and genotype of the Dengue out-break with the help of molecular characterization and genotyping of dengue virus based on gene sequencing.
- To study the genetic variation in dengue virus.
- Molecular screening of dengue virus in mosquitoes collected from field for early warning signals.
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| RP.6 DNA sequence homology of pla and f1 genes of Yersinia pestis during outbreak |
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Broad objectives
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- Carry out molecular diagnosis for confirmation of Yersinia pestis based on specific pla and f1 gene at the time of any eventuality of suspected outbreak.
- To carry out the molecular characterization and genotyping of Yersinia pestis by gene sequencing and DNA homology.
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| RP.7 Molecular diagnosis of strain differentiation among Leishmania species |
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Broad objectives
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- To carry out molecular diagnosis and confirmation of leishmania in suspected patients.
- To carry-out strain differentiation of leishmania species using molecular techniques.
- To establish the diagnosis and confirmation of different leishmania species using molecular techniques.
- To study the ITS and microsettelite regions in leishmania species and strains.
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| RP.8 Study of the molecular mechanism of anti-microbial resistance in Salmonella species |
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Broad objectives
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- To study the various genes involved in the mechanism of drug resistance in Salmonella species.
- To establish the different genes for drug resistance pattern on the basis of gene mutation and sequencing.
- Expression of acrA gene of salmonella typhi was characterized in about 20 isolates with reference to ciprofloxacin resistant.
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| RP.9 Monitoring of thyroid hormones in sera from suspected cases under NIDDCP |
| Broad objectives |
- To estimate the thyroid hormone levels (Free T3, Free T4 & TSH) in blood sample of suspected cases referred from Govt. hospitals and dispensaries.
- To asses the trend of hyper and hypothyroidism in the tested samples.
- To monitor the thyroid hormone levels in patients on thyroid drug therapy.
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| RP.10 Monitoring of Iodine levels in urine and salt samples under NIDDCP |
| Broad objectives |
- Being recognized as one of the National Reference Laboratory for Monitoring of IDD Programme in the country, the laboratory is providing all technical laboratory support to NIDDCP programme.
- To estimate the iodine content in salt and urinary iodine excretion level in the urine samples collected during surveys.
- Imparts training to Programme Officers and Technical Staff engaged in the programme at different States/UTs for manpower development.
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| RP.11 Analysis of fluoride in water samples collected during fluorosis School surveys |
| Broad objective |
| To analyse the fluoride content in water samples collected during fluorosis surveys to understand the fluoride endemicity in a particular geographical area. |
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| RP.12 Comparision between Anti Measles IgG antibodies using ELISA and Serum Neutralization Test.(In-vitro Cell culture Assay) for the diagnosis of SSPE, a post measles sequelae |
| Broad objective |
| To find out a suitable alternate to ELISA which is a commercial kit based test and many a times not available when diagnostic facility is required for diagnosis of SSPE. |
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| RP.13 Prevalence of Hepatitis B & C in various high risk groups |
| Broad objective |
| To find out the status of Hepatitis B & C in various high –risk groups on terms of exposure, infection and chronicity. |
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| RP.14 Sero- conversion by Hepatitis B vaccination of high risk individuals |
| Broad objective |
| To find out the proportion of high –risk individuals who get protected by Hepatitis B vaccination out of those who take the vaccine. |
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| RP.15 Molecular and Biochemical sensors for identification of cells and diagnosis of disease |
| Broad objective |
- To collect and provide clinical samples obtained from cases of meningococcal disease and cultures for the study
- Preliminary testing of samples by Smear examination, culture and by rapid antigen detection for pygenic meningitis followed by DNA extraction
- Evaluation of biosensors developed at IGIB using a range of clinical samples
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| RP.16 Study of Kala-azar prevalence in Delhi |
| Broad Objective |
| To diagnose suspected Kala-azar cases by parasitological & serological techniques from samples obtained from different Delhi Hospitals. |
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| RP.17 Production and standardization of Leishmania antigen for serological tests. |
| Broad Objective |
| Maintenance of reference strain and preparation and standardization of antigen from reference Leishmania strains for serological tests. |
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| RP.18 Sero-epidemiology of Brucellosis in Rural and Urban Population |
| Broad Objective |
| To screen PUO cases for Brucellosis and to find out the prevalence rate in Rural and Urban population. |
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| RP.19 Surveillance of Arbovirus Infections in man and animals |
| Broad Objective |
| To study the activity of Gr.B Arbovirus in man and animals with special emphasis on Dengue, Japanese encephalitis and Chikungunya viruses. |
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| RP.20 Serological Studies for Toxoplasmosis |
| Broad Objective |
| To study the sero-prevalence of Toxoplasmosis in women with bad obsteric history (BOH) and neonates. |
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| RP.21 Survey of Rabies infection in dog population |
| Broad Objective |
| To determine the prevalence of rabies infection in the dog population in Delhi. |
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| RP.22 To study the epidemiology of Rabies in man and animals |
| Broad Objective |
| To study the epidemiology of Rabies in man and animals as a baseline data for effective implementation of Rabies Control in the country. |
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| RP.23 Detection of Rabies neutralizing antibodies by rapid techniques in a) man; b) animals |
| Broad Objectives |
| To determine the rabies neutralizing antibodies in sera of man and animals using 1) mouse neutralization test, ii) counter immuno-electrophoresis and iii) ELISA techniques. |
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| RP.24 Surveillance of plague in states of Andhra Pradesh, Tamil Nadu, Karnataka, Gujarat and Maharashtra |
| Broad Objectives |
- To provide laboratory support for surveillance of plague in states mentioned
- To detect early warning signal, so that state authorities can be alerted for preventing any possible outbreak of plague.
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| RP.25 Incidence of neuro-cysticercosis in patient with epilepsy |
| Broad Objectives |
• To find out incidence of neurocysticercosis in patients with epilepsy
• To study the association of disease with risk factors
• To correlate the clinical and radiological findings with serological findings. |
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| RP.26 Sero-epidemiology of Rickettsiosis in human and animal population |
| Broad Objectives |
- To screen PUO cases and rodents for Rickettsiosis
- To study the epidemiology in positive cases.
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| RP.27 Sero-epidemiology of Human Leptospirosis |
| Broad Objective |
| To develop appropriate serodiagnostic methods and to conduct sero-surveillance studies in man. |
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| RP.28 Serological studies on Hydatidosis in Man and Animals |
| Broad Objective |
| To study the prevalence of Echinococcosis among domestic animals and human population. |
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| RP.29 Studies on the Bionomics and ecology of Aedes aegypti, a vector of dengue/DHF in Delhi |
| Broad objectives |
- To study the Seasonal prevalence, distribution, population dynamics of dengue vectors using standard entomological techniques in a few selected localities of Delhi
- To determine the preference of breeding habitats of Aedes aegypti
- Seasonal changes in breeding preferences of Aedes aegypti
- To forecast the early warning signals about the occurrence of the disease based on entomological indices.
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| RP.30 A study on the Aedes aegypti breeding potential at Railway Stations and Inter-State Bus Terminals (ISBTs) of Delhi |
| Broad objective |
| To assess dengue vector breeding during the peak transmission season at Railway Stations and Inter-State Bus Terminals of Delhi |
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| RP.31 Japanese Encephalitis /Dengue virus detection in mosquitoes of some endemic areas |
| Broad objectives: |
- To detect JE virus in Culicine mosquitoes by antigen capture enzyme immunoassay (ELISA)
- To detect Dengue virus in vectors mosquitoes (Aedes aegypti and Ae. albopictus)
- To find out the viral activities in vector mosquitoes in relation to disease transmission
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| RP.32 : Development of a protocol for entomological surveillance & early warning signal for Dengue outbreak in Delhi and Sonipat (Haryana) |
| Broad objectives: |
- To know the seasonal dynamics of the Dengue vector Aedes aegypti in relation to Dengue virus activity in mosquitoes.
- To develop a method for vector surveillance and early warning signal for Dengue outbreak.
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| NCDC Branches |
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| RP.33 An epidemiological study of Brucellosis in Alwar district. |
| Broad Objective |
| To find out the distribution of the disease vis a vis suggest measures for it’s control and prevention. |
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| RP.34 Studies on Defluoridation of water using Natural Resources |
| Broad Objective |
| Evaluation of defluoridation of water using Natural Resources |
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| RP.35 Serological Diagnosis of Rickettsial Disease in Human beings, Preparation and Standardization of Weil Felix Test antigen in Bangalore |
| Broad Objective |
| Preparation and Standardization of Weil Felix Test. |
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| RP.36 Preparation and Standardization of Weil Felix Test antigen and Sero-surviellance of Rickettsial Disease in Human and Rodent Population in Salem District, Tamil Nadu |
| Broad Objective |
| Sero-surviellance of Rickettsial Disease in Human and Rodent Population in Chittor district, Andhra Pradesh |
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| RP.37 A study on Aedes aegypti (L) mosquito in Jagdalpur town & suburbs and serological confirmation of dengue cases". |
| Broad objectives |
- To know prevalence of Aedes aegypti, a vector of dengue
- To know the incidence of dengue cases by serological confirmation.
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| RP.38 Study to monitor the Aedes larval indices in Alappuzha and Kozhikode districts |
| Broad objective |
| To monitor the different larval indices of Aedes mosquitoes, the vectors of Dengue and Chikungunya in Alappuzha, Cherthala and Kozhikode towns. |
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| RP.39 Study on JE/Dengue virus detection in mosquitoes of some endemic states – an RFTRC-NICD collaborative study |
| Broad objectives |
• To detect JE virus in culicine mosquitoes by antigen capture enzyme Immunoassay.
• To detect dengue virus in vector mosquitoes (Aedes aegypti and Ae. albopictus) by antigen capture enzyme immunoassay. |
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| RP.40 Study on Vector & Vector control activities in Tribal Dominated Malaria Endemic Districts of Andhra Pradesh. |
| Broad Objectives |
- To evaluate quality of on-joining Vector Control Operations in malaria endemic tribal dominated Villages.
- To note present Anopheline species in different Biotopes and their susceptibility status commonly used Insecticides.
- To collect the reasons of Short-fall in vector control Operations , in village level and to suggest remedial measures against it.
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| RP.41 Lymphatic Filariasis in Weavers community in East & West Godavari Districts, Andhra Pradesh. |
| Broad Objectives |
- To evaluate the magnitude of lymphatic filariasis among weavers’ community in East & West Godavari Districts of Andhra Pradesh
- To note extent of mf carriers in the community
- Transmission dynamics and the community participation in MDA Programme
- Necessary steps to prevent transmission in the community with the help of State Government
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| RP.42 Study on prevalence of soil transmitted Helminthis, L.F and Yaws in tribal dominated area of W.Godavari Dist. |
| Broad Objectives : |
- To note the prevalence of Soil Transmitted Helminthis (STH) and Lymphatic Filariasis in remote tribal dominated villages of West Godavari District of Andhra Pradesh.
- To note the prevalence of sero-positive cases of Yaws in children under 5 years in the past yaws affected villages as well as yaws free villages.
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| RP.43 Field evaluation of permanet (long lasting insecticide –impregnated bed nets) against filaria vector mosquitoes near Chandauli district- A multicentric field trial of Division of Medical Entomology & Vector Management, NCDC, Delhi. |
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- To evaluate the efficacy of Insecticide Impregnated Bed nets against Filaria vectors.
- To study the vector bionomics (distribution, density, seasonal prevalence, feeding, resting behavior & longevity.
- To find out the vector infection rate & infectivity rate and Microfilaria & disease rate.
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| RP.44 A study on the prevalence and distribution of Aedes aegypti in Varanasi city |
| Broad objectives : |
- To study the Prevalence, Distribution and Density of Aedes aegypti mosquitoes
- To identify various breeding sources in residential areas of Varanasi City &
- To assess the Potential in supporting Aedes aegypti breeding in urban population
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| RP.45 Laboratory and field evaluation studies on the mosquito insecticidal/repellent properties of some indigenous plants |
| Broad objectives |
- To scan indigenous plants for their insecticidal properties
- To extract the essential oils of promising plants and to evaluate their mosquito insecticidal and repellent properties both under laboratory and field conditions
- To identify the active ingredients of the plants oils causing larvicidal and repellent properties
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| RP.46 Examination of Blood smears by using Og4C3 antigen ELISA |
| Broad objectives |
| Feasibility of using Og4C3 antigen ELISA using dried Blood spot (DBS) as a tool for detection of Wuchereria bancrofti antigenemia under Lymphatic Filariasis Elimination Programme (LFE). |
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| RP.47 Evaluation of Rapid Diagnostic test kit for diagnosis of Kala-azar cases in Bihar. |
| Broad objective |
| To evaluate different Rapid Diagnostic Test kit for diagnosis of Kala-azar. |
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| RP.48 Field trial of LLIN (Permanet) against sandfly (P.argentipes), the vector of Kalaazar in Bihar |
| Broad objectives |
- To assess the efficacy of the net against P.argentipes, the vector of kala azar in Bihar.
- To assess the acceptability level among users and collateral benefit of net
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